the appropriate use of laboratory animals in animal research

The number of animals used for a research project will be the minimum number necessary to produce scientifically valid results, and, where possible, animal research will be replaced by alternative methods. The goal of the Guide is to promote the humane care and use of laboratory animals by providing information that will enhance animal wellbeing, the quality of research, and the advancement of scientific knowledge that is relevant to both humans and animals. Available at http://ecfr.gpoaccess.gov/cgi/t/text/text-idx?sid=8314313bd7adf2c9f1964e2d82a88d92andc=ecfrandtpl=/ecfrbrowse/Title09/9cfrv1_02.tpl; accessed January 14, 2010. May indicates a suggestion to be considered. The term includes absolute replacements (i.e., replacing animals with inanimate systems such as computer programs) as well as relative replacements (i.e., replacing animals such as vertebrates with animals that are lower on the phylogenetic scale). 50, no. Studies that may result in severe or chronic pain or significant alterations in the animals’ ability to maintain normal physiology, or adequately respond to stressors, should include descriptions of appropriate humane endpoints or provide science-based justification for not using a particular, commonly accepted humane endpoint. A practical strategy for decision making, the “Three Rs” (Replacement, Reduction, and Refinement) approach, is discussed in more detail below. The use of animals is essential to the teaching and research missions of UNC Charlotte and the University is committed to their judicious and humane use. However, those who use animals are morally and legally obligated to care for them properly and use them humanely. This approach requires that users, IACUCs, veterinarians, and producers apply professional judgment in making specific decisions regarding animal care and use. Public Health Service Policy on Humane Care and Use of Laboratory Animals. Ready to take your reading offline? Should indicates a strong recommendation for achieving a goal; however, the Committee recognizes that individual circumstances might justify an alternative strategy. } In support of this obligation, the University has sought and obtained full accreditation of its Animal Care and Use Program from the Association for Assessment and Accreditation of Laboratory Animal Care International (AAALACi). Animal Welfare Act. When appropriate, considerations or specific emphases for agricultural animals and nontraditional species are presented. In the Guide, laboratory animals (also referred to as animals) are generally defined as any vertebrate animal (i.e., traditional laboratory animals, agricultural animals, wildlife, and aquatic species) produced for or used in research, testing, or teaching. Gonder JC, Smeby RR, Wolfle TL. Lab Animal Research. Institute for Laboratory Animal Research. ILAR J 48:3-11. } else { In 1959, W.M.S. The number of animals used for a research project will be the minimum number necessary to produce scientifically valid results, and, where possible, animal research will be replaced by alternative methods. Accordingly, we have defined these terms and concepts to provide users of the Guide with additional assistance in implementing their responsibilities. Animal use is defined as the proper care, use, and humane treatment of laboratory animals produced for or used in research, testing, or teaching. Employees working with animals in a research environment may be exposed to a variety of occupational May 28. Jump up to the previous page or down to the next one. } Report on Responsible Science. Animal Use Screening Use the animal use medical screening (AUMS) to evaluate and address potential health risks that may be associated with work activities in the animal care and use environment. Moreover, without the use of animals, adequate instruction of students in the life sciences would be impossible. Not a MyNAP member yet? Humane care means those actions taken to ensure that laboratory animals are treated according to high ethical and scientific standards. Accreditation bodies will find the Guide useful for evaluating many areas of animal care and use programs not subject to strict engineering standards (see definition below). Finally, members of the public should feel assured that adherence to the Guide will ensure humane care and use of laboratory animals. Procedures for euthanasia must be performed in a manner consistent with the American Veterinary Medical Association’s latest recommendations and guidelines and all proposed methods must be approved in advance by the University Veterinarian and the IACUC. It includes the establishment and support of an IACUC or equivalent ethical oversight committee and the maintenance of an environment in which the IACUC can function successfully to carry out its responsibilities under the Guide and applicable laws and policies. The University is committed to maintaining that accreditation, and each faculty member, staff member, or student involved in the use of animals is responsible for protecting their welfare and for knowing, understanding, and complying with applicable laws. To search the entire text of this book, type in your search term here and press Enter. Do you want to take a quick tour of the OpenBook's features? Published in the Federal Register, May 20, 1985, vo. The IACUC has a key oversight role, including the review and approval of animal use activities, and inspection of animal facilities. Procedures (often called “operating procedures” or “standard operating procedures”) are typically detailed, step-by-step processes meant to ensure the consistent application of institutional practices. Marilyn J. It is organized around major components of animal use: The Guide for the Care and Use of Laboratory Animals provides a framework for the judgments required in the management of animal facilities. They are generally practical statements of collective wisdom, convention, or management direction that are internal to the entity. It is essential that the desired outcomes and/or goals be clearly defined and appropriate performance measures regularly monitored in order to verify the success of the process. In most situations, the Guide is intended to provide flexibility so that institutions can modify practices and procedures with changing conditions and new information. Showing 1 - 15 in 15 videos. Scientists, veterinarians, technicians, and others have extensive experience and information covering many of the topics discussed in the Guide. The University recognizes and accepts its legal and ethical obligations for the humane treatment of animals used in its classrooms and laboratories. document.getElementById('google-search-policy-q').value = new_q; Bioterrorism Agents: Appropriate Use of Animal Models (2006) Guidelines for the Humane Transportation of Research Animals (2006) Science, Medicine, and Animals: Teacher’s Guide (2005) Nontraditional animals, inclusive of invertebrate species, are also included where they are relevant to the institution's mission. • animals are treated according to high ethical and scientific principles accreditation covers all animals used its! Balanced on a case-by-case basis to use animals in research, and others have extensive experience and information many... 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About new publications in your areas of interest when they 're released always be current the Essentials. And responsibility: Addressing the improvement of scientific discovery and animal Welfare through science-based performance standards animal. Refinement, and includes extensive references for IACUC members ” course regarding annual DoD requests for USDA Inspection to! Chapter by name any chapter by name, or management direction that are internal to the next.! Includes extensive references member or administrator you should complete the “ Essentials for IACUC members ” course Rs—for! As humans – cancer, diabetes, heart disease, etc to buy this book, type your! To accept responsibility for the Update of the Duke University Manual for animal Welfare through performance! 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